Evaluating Healthful Properties of Cereals and Cereal Fractions by Their Bile-Acid-Binding Potential
T. S. Kahlon. Western Regional Research Center, USDA-ARS, Albany, CA, U.S.A. Cereal Foods World 54(3):118-121.
An in vitro bile acid binding which does not require the use of labeled isotopes, is a valuable tool for screening food fractions for their healthful potential before animal and human studies are warranted. The healthful, cholesterol-lowering (atherosclerosis amelioration) or detoxification of harmful metabolites (cancer risk reduction) potential of cereals and cereal fractions could be predicted by evaluating their in vitro bile acid binding under physiological conditions. Using equal dry matter per incubation the in vitro bile acid binding relative to cholestyramine (cholesterol-lowering bile acid binding drug) was rice bran 13–25%, wheat bran 16–20%, oat bran 5%, barley 5–6%, and corn bran 3%. Relative bile acid binding of wheat bran by processing could be further enhanced by 6–15%. The mean relative bile-acid-binding values for single grain wheat, oat, rice, and corn cereals were 9.4, 8.6, 2.8, and 2.1%, respectively. Since wheat bran has been shown to lower the risk of cancer, similar bile acid binding of rice bran and wheat bran suggest that rice bran should be tested for its cancer risk reduction.